Adverse Effects of Lead Treatment: Relationship of Histopathological Changes and Protective Role of Sodium Selenite on Non-Diabetic and Diabetic Rat Hearts
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چکیده
The present study was designed to examine the effects of lead nitrate (LN) and whether selenium has a cardioprotective effect on diabetic and non-diabetic rats. Selenium and LN were administered orally for 28 days to streptozotocin-induced diabetic and non-diabetic rats. Animals were divided into 8 groups: control, sodium selenite, LN, LN+Sodium selenite, diabetic-control, diabetic sodium selenite, diabetic LN and diabetic LN+Sodium selenite. In our present study LN and diabetes caused histopathological changes in heart of animals. We found that sodium selenite treatment did not show protective effect on diabetes mellitus (DM) caused damages. However it showed protective effect against LN but, not completely shown a protective.
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